Inhibition of in vitro Tubulin Assembly
IN VITRO TUBULIN ASSEMBLY, IC50 (mM)
DRUG
30°, 0.8 M Glu (no MgCl2)
37°, 1.0 M Glu, 1mM MgCl2
Hemiasterlin
1.0 ± 0.02
2.9 ± 0.10
Hemiasterlin A
1.1 ± 0.10
3.1 ± 0.04
Hemiasterlin C
1.3 ± 0.01
3.2 ± 0.50
Dolastatin 10
0.6 ± 0.05
1.6 ± 0.30
Cryptophycin 1
3.3 ± 0.60
Cryptophycin 1 and all three hemiasterlins inhibit in vitro tubulin assembly similarly, approximately half as potently as dolastatin 10.
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