Each curve for a sample is an A₂₈₀ scan (5 minute intervals) from the tops to bottoms of tubes after reaching 35,000 rpm (sample height at t₀ ~1 cm).

[Explanatory Diagrams]

[Experimental Data] Conclusions: 1) These drugs all induce tubulin oligomers that sediment more rapidly than tubulin alone. 2) The effects of the various drugs are distinct. 3) Mathematical analyses indicate the presence of two predominant, oligomeric species in the presence of hemiasterlin* and vinblastine. * [Hemiasterlin] is substoichiometric. After ~12 hours, only the 19.0 s species is detected (data not shown).

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